Phospho stat4

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August undefined, 2024

WebThe Phospho-STAT4 (Tyr693) assay provides a quantitative measure of the data obtained with the traditional Western blot. Phospho -STAT4 (Tyr693) Kit Kit Size Catalog # 1 plate K150PAD-1 5 plates K150PAD-2 25 plates K150PAD-4 20 µg lysate per lane MSD Phosphoprotein Assays WebSTAT4 forms homodimers and heterodimers with related STAT family members. Tyrosine phosphorylated STAT4 can bind the IFN-gamma activated site (GAS). Serine phosphorylation of STAT is also required for maximal transcriptional activity. STAT4 expression is restricted to the thymus, spleen and testis.

检测培养细胞系中磷酸化-STAT1（pTyr (pTyr701),磷 …

WebHuman Phospho-STAT4 (Y693) Antibody Summary Species Reactivity Human Specificity Detects human STAT4 when phosphorylated at Y693. Source Polyclonal Rabbit IgG Purification Antigen Affinity-purified Immunogen Phosphopeptide containing human Phospho-STAT4 Y693 site Formulation Lyophilized from a 0.2 μm filtered solution in PBS. WebStat4 is predominantly expressed in the spleen, thymus, and testis and has been most extensively investigated as the mediator of IL-12 responses (3-8). Activation of Stat4 is associated with phosphorylation at Tyr693 (9). Stat4 is activated in response to IL-2 in natural killer (NK) cells, but not in T cells (10). greater peace baptist church opelika alabama

Phospho STAT4 (Tyr693) Kit Meso Scale Discovery

WebSynthetic peptide within Human STAT4 (phospho Y693). The exact sequence is proprietary. A phospho specific peptide corresponding to residues surrounding Y693 of Human STAT4. Database link: Q14765 Positive control IL4-treated HepG2 cell extract; Human breast carcinoma tissue. General notes WebJun 15, 2001 · The decrease of STAT4 protein appears to be due to specific degradation of phospho-STAT4, possibly through the proteasome degradation pathway. Decreased levels of STAT4 protein lead to decreased STAT4 DNA-binding activity and reduced proliferation and secretion of IFN-gamma. This down-regulation of STAT4 is specific for IL-12 … greater peace baptist church live

STAT4 Requires the N-terminal Domain for Efficient …

Phospho-STAT4 (Tyr693) Monoclonal Antibody …

WebSTAT4 forms homodimers and heterodimers with related STAT family members. Tyrosine phosphorylated STAT4 can bind the IFN-gamma activated site (GAS). Serine phosphorylation of STAT is also required for maximal transcriptional activity. STAT4 expression is restricted to the thymus, spleen and testis. WebA key component in the activation of Stat4 is the phosphorylation on tyrosine and serine residues in response to IL-12 stimulation. IL-12 stimulation leads to the phosphorylation … greater peace baptist church akron ohioWebThe Phospho-STAT Panel Kit measures phosphorylated STAT3, STAT4, and STAT5a,b in the same well. The singleplex kits allow for measurements of phosphorylated and total levels … flinton 2 seater sofa

"WebApr 14, 2024 · Phospho-STAT3 (Y705) Antibody - Prepare a 100X working concentration of the antibody by reconstituting with 110 L of 1X PBS. After reconstitution, store at 2-8° C for up to 30 days or aliquot and store at -20° C in a manual defrost freezer for up to 60 days.* Total STAT3 Antibody - Prepare a 100X working concentration of the antibody by " - Phospho stat4

Phospho stat4

WebFabgennix Anti-Phospho-STAT4 (Ser721) Polyclonal, Catalog # PSTAT4-440AP. Tested in Western Blot (WB), Immunoprecipitation (IP) and ELISA (ELISA) applications. This … WebFeb 19, 2024 · Little is known about the effects on hyaluronan (HA) metabolism of UVA radiation. This study demonstrates that the secretion of HA by human dermal fibroblasts (HDFs) is downregulated by UVA, accompanied by the down- and upregulation of mRNA and protein levels of the HA-synthesizing enzyme (HAS2) and the HA-degrading protein, …

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WebSTAT4 (Tyr693) In-Cell ELISA Kit See all STAT4 kits Detection method Colorimetric Sample type Adherent cells Assay type Cell-based (qualitative) Assay time 5h 10m Assay duration Multiple steps standard assay Species reactivity … WebSep 4, 2002 · Anti-STAT4 and anti-phosphoserine STAT3 antibodies have been described ( 30 ). Anti-phospho STAT4 antibody was from Zymed, anti-phospho p38 and phospho MKK3/6 antibodies were from Cell Signaling Technology (Beverly, MA), and anti-p38 antibody was from Transduction Laboratories (Lexington, KY).

WebImmunogen. Synthetic peptide corresponding to human STAT4 phosphorylated at tyrosine 693. Formulation. Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA) Preparation. The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. WebSTAT4 mediates cytokine signaling by acting as a signal transducer in the cytoplasm and, upon phosphorylation, homo or heterodimerizes with other STAT proteins, which then …

http://sigma-aldrich.cnreagent.com/pdetail407557.html WebSTAT4 phosphorylation was detected using anti-phospho-STAT4 antibody (Zymed Laboratories, Inc., South San Francisco, CA), followed by stripping and reprobing the membranes with polyclonal antibody against the C …

WebNitro-oleic acid (NO2-OA), pluripotent cell-signaling mediator, was recently described as a modulator of the signal transducer and activator of transcription 3 (STAT3) activity. In our study, we discovered new aspects of NO2-OA involvement in the regulation of stem cell pluripotency and differentiation. Murine embryonic stem cells (mESC) or mESC-derived …

WebApr 12, 2024 · The effect of FLU on STAT3 expression and activation in A172 and T98G cells. (A) The time dependence of FLU effect on STAT3 and phospho-STAT3 (Tyr705) … flinton chalkWebOct 15, 2002 · Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling In this study we demonstrated that CD4(+) T cells from STAT4(-/-) mice exhibit reduced IL-12R expression and poor IL-12R signaling function. flinton east yorkshireWebPhospho-MAPK Family ELISA Sampler Pack Pim Kinase ELISA Sampler Pack Pyroptosis ELISA Sampler Pack Reactive Cell Death and Autophagy ELISA Sampler Pack Reactive Inflammasome ELISA Sampler Pack Receptor Tyrosine Kinase ELISA Sampler Pack SARS-CoV-2 Virus-Host Interaction ELISA Sampler Pack flint oncologyWebJun 28, 2004 · Anti-phospho-Stat4 and -IRF3 antibodies were purchased from Zymed Laboratories Inc. (CA). Anti-Stat1 and -Stat4 antibodies were purchased from Santa Cruz Biotechnology (CA). LPS challenge. Mice were injected intraperitoneally with the indicated doses of LPS dissolved in sterile PBS. The mice were monitored for lethality for 120 h … flinton grove bd2WebImmunogen. Synthetic peptide corresponding to human STAT4 phosphorylated at tyrosine 693. Formulation. Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide … flinton falls ontarioWebApr 13, 2024 · The protective effect of copolymer I in EAE partly inhibits STAT4 and STAT3 phosphorylation in T cells, suppressing Th1 and Th17 cell differentiation . Several herbal compounds and pyridinol derivatives, including plumbagin, berberine, and BJ-2266, exert protective effects in EAE disease models by inhibiting STAT activation and repressing Th1 … flinton check waterproof rain bootWebA nuclear phospho-tyrosyl phosphatase TC-PTP has been shown to dephosphorylate STAT1. STAT1 is exported back to the cytoplasm and this terminates STAT1-stimulated gene expression. ... The STAT4 and STAT1 genes are neighbors on chromosome 2 and encode proteins that belong to a family of transcription factors originally isolated by their … flinton grove hull